Nutrition is at the core of integrative health and our Micronutrient Testing is the most advanced diagnostic tool available.Micronutrient testing measures how micronutrients are actually functioning within your patients' white blood cells. These tests allow nutritional assessment of your patients for a broad variety of clinical conditions, general wellness and the prevention of chronic diseases including arthritis, cancer, cardiovascular risk, diabetes, various immunological disorders and metabolic disorders.
Micronutrient test includes:
|Vitamin A||Vitamin B1||Vitamin B2||Vitamin B3||Vitamin B6||Vitamin B12|
|Biotin||Folate||Pantothenate||Vitamin C||Vitamin D||Vitamin K|
|Alpha Lipoic Acid||Coenzyme Q10||Cysteine||Glutathione||Selenium||Vitamin E|
|Chromium||Fructose Sensitivity||Glucose-Insulin Metabolism|
for Total Antioxidant Function
Immune Response Score
Poor blood sugar regulation and unhealthy triglyceride and lipoprotein levels often present long before a diagnosis of Type 2 Diabetes. SpectraCell’s CardioMetabolic, Pre-Diabetes, and LPP™ Plus Tests offer clinically relevant evaluation to help define risk for atherosclerotic cardiovascular disease (ASCVD), progression toward Type 2 Diabetes, and inflammation. These check points, along with a new CardioMetabolic Risk Assessment and Type 2 Diabetes Risk Assessment, help patients understand that not just one factor, but rather a constellation of factors, contributes to the genesis and progression toward cardiovascular disease including stroke, poor blood glucose control including Type 2 Diabetes, and/ or inflammation. Test results allow doctors to know when guidance, educational referral, and/ or treatment are necessary. Key components of the CardioMetabolic Test are listed below.
- Lipoprotein Fractionation
- Lipoprotein Particle Numbers
- Total Cholesterol
- HDL Cholesterol
- LDL Cholesterol
- Lipoprotein (a)
- Apolipoprotein A-1
- Apolipoprotein B
- Hemoglobin A1c
- CardioMetabolic Risk Assessment
- Type 2 Diabetes Assessment
- Estimated Average Glucose (eAG)
- Homeostatic Model Assessment of
- Insulin Resistance (HOMA-IR)
New life solutions offers comprehensive male and female hormone panels that reveal the overall state of hormonal balance in a patient. Like nutrients, hormones influence all aspects of health and disease - mood, sleep, metabolism, immunity, heart health and appearance. An imbalance of one hormone can initiate cascade of events that alters other hormones, so a comprehensive look at hormone status is key.
Thyroid hormones directly regulate every cell in our body as most basic functions like metabolism, emotions and thinking. We also test several proteins that affect thyroid function as well as antibodies to thyroid which can detect autoimmunity (when the immune system attacks healthy tissue) and your levels of cortisol, the stress hormone.
Hormones & Makers
- Dehydroepiandrosterone sulfate (DHEAS) - the most abundant sex hormone in the body, DHEAS (the sulfated, or bioavailable for of DHEA), is produced by the adrenal glands is the precursor hormone to testosterone and estrogens. DHEAS enhances immunity, reduces autoimmunity, helps prevent cancer, and improves insulin sensitivity, bone health and cognitive function.P,E
- Androstenedione - precursor hormone to both testosterone and estrogens; occurs in equilibrium with testosterone so an increase in one also increases the other.P
- Testosterone - clinically associated with increased muscle mass, libido, bone health and a general sense of well being.E
- Estradiol (E2) - the strongest estrogen; protects blood vessels, increased high density lipoprotein-cholesterol (HDL), prevents bone loss, helps form collagen which benefits the appearance of the skin, improves cognitive function and increases the immune response. However, estradiol also exerts a strong proliferative effect on hormone sensitive tissues like the breast, uterus and ovary so it must be properly balanced with progesterone and other estrogens to prevent the clinical manifestation of estrogen dominance and related cancers.E
- Estrone (E1) - This estrogen has very strong tissue proliferative effects and may be linked to estrogen dominant conditions like fibrocystic breasts, endometriosis and uterine fibroids. It will create either dangerous or benefical metabolites, depending on a person's nutritional status.
- Estriol, unconjugated (E3) - weaker estrogen; protective against cancer as it opposes the proliferative effects on the uterus, breast and ovary from the stronger estrogens; particularly high during pregnancy.E
- Progesterone - selectively balances the effects of estrogen in hormonally sensitive tissue (breast, uterine) as well as in the brain and skin. Progesterone decreases the immune response, promotes bone formation, protects the brain and tends to have a calming effect on mood. It is also a precursor hormone for other sex hormones as well as cortisol and interacts with hormones to regulate metabolism.P,E
- P - Precursor hormone - typically converted to other hormones
- E - End point hormone - acts directly on tissues for physiologic effects
- R - Regulating hormone - initiates the production or suppression of other hormones
Regulatory (Peptide) Hormones
- Follicle stimulating hormone (FSH) - stimulates the production of estrogens; marker of ovarian function in women and initiates sperm production in men.
- Luteinizing hormone (LH) - contributes to reproductive function in both men and women; responsible for ovulation in women and sperm production in men; works synergistically with FSH and largely affected by prolactin levels.
- Prolactin (PRL) - an inhibitory hormone that reduces the action of several other hormones; most known for its ability to stimulate milk production in lactating women but it also regulates calcium metabolism and plays a role in the synthesis of nerve cells and prostaglandins as well, in both men and women.
- Sex hormone binding globulin (SHBG) - produced in the liver and regulated by other hormones, SHGB is a protein that binds estrogens and testosterone in the bloodstream so they are biologically inactive.
- Free T3 (Free Triiodothyronine) – the more potent and biologically active thyroid hormone, T3 regulates growth and metabolism throughout the whole body.
- Free T4 (Free Thyroxine) – considered a precursor hormone, T4 is converted to T3 as required by cells throughout the body; levels of T4 are generally much higher than T3.
- Total T4 (Total Thyroxine) - Most T4 in the blood is bound to carrier proteins which make it biologically inactive. Total T4 includes unbound (free) T4 plus T4 that is bound to carrier proteins in the blood.
- rT3 - Reverse T3 (Reverse Triiodothyronine) - As the name implies, Reverse T3 opposes the biological action of T3. It slows metabolism and renders T3 in the body biologically inactive. The rate of rT3 production relative to T3 will increase in times of stress (high cortisol) and in the presence of nutrient deficiencies, inflammation or certain medications.
- Thyroid Stimulating Hormone (TSH) – produced by the pituitary gland, TSH tells the thyroid gland to increase or decrease production of T4 or conversion to T3 depending on the amounts circulating in the bloodstream via an efficient feedback system.
- Anti-TG (Antibodies to Thyroglobulin) – a precursor to T4. If Anti-TG are present in significant amounts, this suggests an abnormal immune response against your own body, also called autoimmunity.
- Anti-TPO (Antibodies to Thyroperoxidase) – is an enzyme that initiates the synthesis of T4. Antibodies to TPO indicate autoimmunity where the body is attacking normal proteins in the blood (in this case, TPO). People with anti-TPO have a higher chance of developing hypothyroidism that those who do not have antibodies to TPO.
- Tg (Thyroglobulin) – The main function of Tg is to store iodine, which is a necessary nutrient for the production of thyroid hormones T3 and T4. This test is particularly useful when monitored over time versus a single measurement and can sometimes be a useful tumor marker in patients with previous thyroid cancer.
- TBG (Thyroid Binding Globulin) – is a carrier protein for thyroid hormones so its role is to transport T4 and T3 through the bloodstream. The thyroid gland adjusts to changing levels of TBG in order to keep free T4 constant and it is particularly useful when thyroid (T4) levels do not necessarily correlate with clinical symptoms. TBG levels are largely affected by other hormones and many prescription drugs and is useful in diagnosing the reason behind abnormal thyroid hormone levels.
The first commercially available telomere analysis in the United States.
A window to your patient’s cellular health.
What does Telomere Testing measure?
Telomeres are sections of genetic material at the end of each chromosome whose primary function is to prevent chromosomal “fraying” when a cell replicates. As a cell ages, its telomeres become shorter. Eventually, the telomeres become too short to allow cell replication, the cell stops dividing and will ultimately die - a normal biological process. SpectraCell’s Telomere Test can determine the length of a patient’s telomeres in relation to the patient’s age.
How are the results reported?
The Patient Telomere Score is calculated based on the patient’s average telomere length in peripheral whole blood cells. This average is then compared to telomere lengths from a population sample in the same age range as the patient to determine the patient’s percentile score.
What do the results mean to the patient and the doctor?
Cellular attrition by analyzing the rate at which changes in average Telomere length occur over time. Cells are being lost and replaced. (Cellular attrition)
What are the nutritional implications on telomere length and repair?
An inflammatory diet, or one that increases oxidative stress, will shorten telomeres faster. This includes refined carbohydrates, fast foods, processed foods, sodas, artificial sweeteners, trans fats and saturated fats. A diet with a large amount and variety of antioxidants that improves oxidative defense and reduces oxidative stress will slow telomere shortening. Consumption of 10 servings of fresh and relatively uncooked fruits and vegetables, mixed fiber, monounsaturated fats, omega-3 fatty acids, cold water fish, and high quality vegetable proteins will help preserve telomere length. In addition, it is advised to reduce total daily caloric intake and implement an exercise program. Fasting for 12 hours each night at least 4 days per week is recommended.
What lifestyle modifications are likely to be helpful?
One should achieve ideal body weight and body composition with low body fat (less than 22 % for women and less than 16 % for men). Decreasing visceral fat is very important. Regular aerobic and resistance exercise for at least one hour per day, sleeping for at least 8 hours per night, stress reduction, discontinuation of all tobacco products are strongly recommended. Bioidentical hormone replacement therapy may decrease the rate of telomere loss.
When should retesting be considered?
Testing should be done once per year to evaluate the rate and direction of telomere changes and make adjustments in nutrition, nutritional supplements, weight management, exercise and other lifestyle modifications known to influence telomere length.
What role will nutritional supplements play in slowing telomere shortening?
Oxidative stress may shorten telomere length and cause aging in cellular tissue. Antioxidant supplements can potentially reduce oxidative stress very effectively, which will ultimately improve oxidative defenses, mitochondrial function, reduce inflammation and slow vascular aging. Targeted supplementation is key, as antioxidants work synergistically and must be balanced to work most effectively and avoid inducing a pro-oxidant effect. Increasing antioxidant capacity at the cellular level is critical to maintaining telomere length.
Recent evidence suggests that a high quality and balanced multivitamin will also help maintain telomere length. Specifically, studies have linked longer telomeres with levels of vitamin E, vitamin C, vitamin D, omega-3 fatty acids and the antioxidant resveratrol. In addition, homocysteine levels have been inversely associated with telomere length, suggesting that reducing homocysteine levels via folate and vitamin B supplementation may decrease the rate of telomere loss. Similarly, conditions such as cardiovascular disease, insulin resistance, diabetes, hypertension, atherosclerosis and even dementia affect telomere length. Correcting subclinical nutritional deficiencies that may contribute to such diseases is crucial for telomere maintenance.
What pharmacologic treatments are known to slow telomere loss?
- Angiotensin converting enzyme inhibitors (ACEI)
- Angiotensin receptor blockers (ARB)
- Renin Inhibitors
- Possibly Calcium channel blockers
- Possibly Serum aldosterone receptor antagonists
- Possibly metformin
- Bioidentical Hormone Replacement Therapy
Control all known coronary heart disease risk factors to optimal levels
- Reduce LDL cholesterol to about 70 mg %, decrease
- LDL particle number and increase LDL particle size.
- Reduce oxidized LDL.
- Increase HDL to over 40 mg % in men and over 50 mg % in women and increase HDL 2 subfraction. Reduce inflammatory HDL and increase protective HDL.
- Reduce fasting blood glucose to less than 90 mg % and 2 hour post prandial or 2 hour GTT to less than 110 mg %. Keep Hemoglobin A1C to about 5.0% and keep insulin levels low.
- Reduce blood pressure to about 120/ 80 mm Hg
- Reduce homocysteine to less than 8 um/L
- Reduce HS-CRP to less than 1.0
- Maintain ideal body weight and composition.
- Stop smoking.
- Treat insulin resistance and metabolic syndrome.
Overall recommendations to maintain telomere length
Some clinicians have recommended reducing all known coronary risk factors, inflammation, oxidative stress, ADMA levels and angiotensin II levels or its action. At the same time, therapy should increase nitric oxide levels and nitric oxide bioavailability, increase arginine, increase endothelial progenitor cells, improve mitochondrial function and increase oxidative defenses. In addition, one should optimize hormone levels, exercise, sleep, nutrition and nutritional supplements. Fasting and caloric restriction should be part of the regimen as well.
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